Tuesday, May 26, 2015

Challenge: Debunk the Gliadin Induced Amyloidosis Theory

I've been doing some serious digging into the science behind gluten, and I believe I've formulated a theory, and I would like it to be challenged. I haven't seen this theory proposed or explored anywhere else, not even among all of the wild claims and hypotheses of the likes of the wild claim masters: Dr. William Davis and Dr. Perlmutter. It truly bothers me that I'm sitting on an understanding that seems to make such perfect sense and would explain so much if true, yet I seem to be the only person thinking it. I'm not afraid to be challenged - the lack of it, in this case, is irritating.

I've a good eye for bullshit, which is why I didn't take Wheat Belly or Grain Brain particularly seriously until the diet surprisingly worked for me. But the more I looked into it, the more silly some of their foundational claims seem.  So I've looked into it for myself, and it seems the following two-step process explains pretty much everything that all of the gluten-free experts seem to be getting wrong:

1. Something or some process damages the gut flora / intestinal permeability, allowing partially cleaved gliadin to enter the bloodstream at a rate greater than the body can handle.  Once damaged, the continued presence of gliadin sustains that damage to the intestines.  This is why 'gluten sensitivity' or autoimmune response to gliadin can occur at any age.

2, Partially cleaved gliadin acts as a catalyst in the amylin/insulin/protein process to misfold proteins into amyloid fibers.

That's it. If these two statements are true, all problems known and claimed to be related to gluten (including celiacs, but also every nutjob like me) suddenly have a foundational biological disruption mechanism that explains pretty much everything else.

If you don't have a medical degree in organic biochemistry and can't make the instant connection from these claims to the "game over" conclusion, I will elaborate.  But first, let me provide supporting arguments for the first two claims.

1. Intestinal Permeability / Gut Dysbiosis / Zonulin (prehaptoglobin-2).

If you're not familiar with the research into Intestinal Permeability or Zonulin, please go research it. If you are familiar with it, this latest study is of interest:

What the actual spark is between the normal intestinal response to gliadin, and full blown intestinal permeability is not fully known, but gut dysbiosis, infection and gliadin itself are suspected.  Given that serum zonulin studies are linking intestinal permeability to a much wider range of illnesses than just celiacs, it's a very important unanswered question.

The study above, however, indicates that partially cleaved gliadin fragments may be entering the bloodstream of anyone eating gluten, just not at high levels without full blown permeability. This reaction explaining studies like this:

Production of interleukin 15 in biopsy culture from non‐coeliac individuals challenged with gliadin peptides (2007)

And this:

Gluten Intake Is Positively Associated with Plasma α2-Macroglobulin in Non-Celiac Young Adults (2015)

This leads me to believe that the gliadin reaction is just a matter of degree and quantity, regulated by the permeability of the intestines. More permeability: more problems.

2. Gliadin Catalyzes Amyloid Formation

This is the connection that I haven't seen anyone, world renowned Doctor, Scheister, or lone whack-job (except me), claim or explain, but I ran across a group of studies researching amyloid formation that were using hydrolized gliadin to induce the misfolding process.

Kinetics of Peptide Aggregation 2011 (full thesis paper from student involved in above study).

Basically, in the presence of insulin, amylin & proteins, gliadin fragments catalyze the formation of amyloid fibrils.  Now, these are all ex-vivo studies, but chemistry being what it is, there's no reason the same thing doesn't happen in-vivo.

So when gliadin enters the blood stream, the body is left to cope with two problems it creates: amyloid fibrils that are difficult to dispose of, and a disruption of the proper functioning of all the different amylin processes when gliadin reacts first.

Without digging in too deep right now amylin disruption would affect appetite, insulin levels, lipid production, along with secondary effects of excess free transglutaminase (along with any other amine/acil bonding catalysts I'm unaware of), and lack of appropriate structure for new tissue, because there's insufficient amylin after reacting with gliadin.

Amyloids are known to aggregate in any region of the body, and the illnesses associated are generally defined by the area they choose to.

The more amyloids that are produced (greater intestinal permeability + more gliadin in the diet), the greater the problems, and that's when the immune systems may kick into high gear. What's generally termed an 'autoimmune' response, is in this situation an adaptive immune response, attempting to target the problem, but with major collateral damage.  In some, that target is directly to the gliadin fragments, in others, it's to the leftover products of the disrupted amyloid process (like transglutaminase), and yet others, it might even be to the other half of the gliadin-produced amyloid. There's no law of nature dictating the adaptive immune response must be to the gliadin.

For that matter, there's no biological law dictating there must be an autoimmune response at all.  In some people, probably most people, it would be all innate immune response, and thus currently not diagnosable.  Without an autoimmune response, the typical result would likely be: excessive hunger, overeating, hypo/hyperglycemia from the amylin/insulin disruption.  Then as amyloids accrue and overwhelm the body's natural ability to remove them: insulin resistance, followed by T2 diabetes, and the progressive amyloidosis organ failures associated there-after that generally kill.  Or if you're really unlucky, Parkinson's or Alzheimer's.

So, if 1 & 2 are correct, gliadin really does affect everybody - the key factor likely being simply how much gliadin gets into the blood.  If it's greater than the body's ability to remove the amyloids, they will become a problem.  If you're unlucky, you'll have an autoimmune response, but if you're lucky, it'll be celiacs, so you'll at least know how to treat it.  If you're luckier, you won't have problems until you turn 40 or 50 when the amyloids that have collected start causing diagnosable problems, and you can take metformin or have bypass surgery or thyroid pills or whatever.  If you're really lucky, you have a strong gut and autophagy response and you get to be one of those 115 year old bastards who attribute their age to bacon, Dr. Pepper, and cigars.

There's more - there's always more; but if you've read this far, I challenge you to debunk my theory. I also invite you to apply my theory to any claim people like Dr. Perlmutter or Dr. William Davis make on behalf of gluten-free, in place of their own explanations.  I invite you to look closely using this theory at the debunking of Dr. Perlmutter and Dr. William Davis by such noted science journalists like Hank Campbell at Science 2.0.  I invite you to look again at Dr. Gibson's double-blind cross-over studies as last-word on GF for the ignorant.  I invite you to submit research links, proclaim this or that, just give me something to work with. I'm a big kid. The silence is deafening.

Until then, though, it's now called "Gliadin-Induced Amyloidosis".  No more of this NCGS nonsense. And I'll stop blogging about it, too, since I'm now bored with the topic having convinced myself I've figured it out.

Thursday, April 30, 2015

A Propellantless Day

I've had one of those days where everything that possibly needed attention has caught up with me and demanded it.  Nothing was done except to deal with crisis after crisis, however minor and irritating and diminutive each crisis may have been.  None of them were particularly serious; they just completely threw the day I had originally planned in my head, while eating scrambled eggs and sausage after my coffee.

Of course, after reading the news and catching up with the continued deterioration of humanity's limited grasp of sanity and civility, I was already in a poor mood.  When I got to work and instead of digging into a project I was finally ready to tackle, I had to deal with a computer hardware failure, and things went downhill from there.

So, to brighten myself up, I'm going to imagine all the good possibilities about the future for a minute or two, and trace a path through all the technological marvels to come.

In just a couple of months, both Skunkworks and EMC2 reach milestones in their development of a fusion device.  Private funding pours in, and they begin their race to the finish line of clean, abundant, cheap energy for the world. Might take a few years...

Meanwhile, Doctors have advanced their understanding of the biomechanics of aging and are fiddling with new drugs to halt and reverse it. Might be a decade or so, but it's looking hopeful.

A breakthrough in carbon-nanotube manufacturing, just at the end of 2015, allows the first industrial manufacturing on a scale suitable for construction materials.

While all this is going on, some Japanese start-up has integrated the new Intel Quatro (quantum chip) into a Hobbit-sized robot, allowing it to be taught tasks and to perform them much better than humans.  Somehow, after selling most of what I own, I manage to get one early in the game, but after all the initial screw ups, so I have a stable model.

Besides doing the laundry and dishes, I teach it carpentry, and get it to make all the furniture I've had building up in my mind over the years but never have time to make.  This gets me mildly famous in small circles, but more importantly, I can afford a couple more robots where I put them to construction work, and I skip the clients and just buy property and have the robots build really nice things, which I then sell to people.

This gets me enough notice where I get approached to design, of all things, the ground side station for a space elevator.  Some nerdy geek working for a rich billionaire space racer drudged up my old architecture thesis and contacted me.

It's a couple of years before they can start construction of the space elevator, so I'm having fun running through multiple designs.  While my diet has mostly controlled my Type 2 Diabetes, it's been no fun eating gluten free this past decade.  Much to my relief, doctors discover the source of intestinal permeability causing billions to suffer, and the food supply is genetically modified to correct the situation.  Pharmaceutical relief soon follows, and I finally get to eat bread and donuts again without concern.

As construction starts on the most elegant design mankind will ever see, the first fusors are hitting the market, completely changing the economy of energy. It's a world-wide economic boom that hasn't been seen since post-WW2.  NASA gets its hand on a fusor, and the first EM Drive probe is launched on one of Bezos' fat penis rockets.  It's going on a tour of the solar system, the moon in 4 days, Mars in 30, Jupiter in 4 months.  It's like the Voyager missions, only compressed.  This one doesn't do anything fancy; it's just fast.  They're already designing a probe for Alpha Centauri, hoping to cut the time to 75 years from 130 with what they learn from the first probe.

But I won't be around for that... or will I?  Merck has released a wildly expensive anti-aging treatment. It's a series of shots and pills and some sort of microwave doohicky you sit in over a couple of months that's supposed to take years off. I'll dutifully wait a couple of years for them to experiment on the Hollywood elite and ugly old rich bastards, and see who lives and dies of interesting and horrifying complications, then I might try it myself.  I'm only 60, at this point.

The first line of the space elevator is up, and they're using it to drag pieces and parts of the satellite station out to GSO. I don't have much to do with that except design the staging ground - they don't need the space station to be beautiful - just the terminal.  My work is pretty much done, but it'll be a couple of years yet before they finish their first "space ship" and anyone does much of anything up there.  

Space travel these past 20 years has been limited mostly to science and specialized industry: some fancy computer chip and industrial manufacturing in low-G.  In fact, that's where the I-mind had to be manufactured, Apple's brain interface technology, which thankfully I had no interest in.  The suicide virus wiped out about 2 billion people in a day - 1/4 of the population.  Along with Apple.  After that, I decided to take the anti-aging treatment.  Why not?  Better than networked suicide.

With no practical need for architects anymore, or most any profession, and looking and feeling 30 again, I pour my money into a private space yacht.  Seats 6 comfortably, 12 in a pinch.  Can hold stores for a good year of travel, and has the latest EM-Warp Drives (no, not FTL - no one's gone there, yet) and 3 Polywells to power it, and can do .75G thrust for limited burst, cruising speed of .25G.  

After touring the solar system, I plan on watching, with my wife and some friends, the controlled Mercury impact into Venus from about .1AU out,  They say it will spin Venus up to a 22 hour rotation, create a moon about the size of Earth's, and create a magnetic field about 1.5 the strength of Earth's.  Mars is fine for retirement, but once Venus is ready... I'm there.

Okay, now I'm in a better mood.

Tuesday, February 10, 2015

Twitter vs. Gluten

I occasionally search #gluten and #glutenfree on twitter, usually when I'm looking for an interesting recipe or for links to news/opinions when I have some time to kill.  Always, there's a spate of the same questions and comments from people.  They don't want an answer, obviously, but I feel compelled to answer anyway, just not on twitter, since I usually don't have the wit of brevity.
Gluten is a protein composite found in wheat, barley, rye, and couple of other grains.  It's primary components are glutenin and gliadin.  Gliadin, in particular, is being implicated in scientific studies as a source of inflammation and disruption of the metabolic process.  Gliadin is also the target of auto-immune issues in Celiacs, and may well be the auto-immune target in Type 1 Diabetics.
There is certainly a large degree of ignorance on this subject in society, but most people have no clue how their computer works, and yet it still does, without discrediting the computer.
Again, one's ignorance of the scientific evidence does not negate the actual scientific evidence. There's plenty of it, and it's accumulating.
Yet again, one's ignorance is not a conclusion.
Gluten is not an important part of any diet. Neither, for that matter, is wheat.  Fortification (the adding of vitamins and nutrients) of wheat is the only basis for any argument regarding the nutritional value of wheat vs. gluten-free grains, and the reason wheat is fortified is because it's not very nutritious.  Even when fortified, several gluten-free grains are still more nutritious than wheat (millet, amoranth, buckwheat).  One really shouldn't be relying on fortification, wheat or any grain carb as nutrition to begin with.
No, but I do remember 35 years ago, when obesity was rare, when eating or drinking too much sugar made one sick and you had to stop, when 12 year-olds weren't being diagnosed with type 2 diabetes, or non-alcoholic fatty liver diseases.  I remember there was a time when no one knew what Celiac's was, or what Alzheimer's was, or Parkinson's, or ALS; not because people didn't have these illnesses, but because they were rare.
Mayhap so. Though I've never judged a fuck, when I give one.

There are several reasons, but the most ubiquitous is that wheat is frequently added to many products that one wouldn't suspect.

Some examples: Many crisped rice cereal often have malted barley added to them for flavoring, which contains gluten.  Soy sauce, despite it's name, is usually prepared with wheat.  Same for Teriyaki sauce.

Other times, products share equipment with those used to make wheat products or harvest wheat, and the contamination can be enough to activate problems in people with severe allergies or auto-immune responses to gluten.  Oats are the prime example of shared harvesting equipment.

Finally, marketers are savvy to ignorance.  If you look at a box of Corn Chex and scream that it shouldn't be labeled "Gluten-Free" because corn has no gluten to begin with, there's someone else looking at it, sighing with relief that they finally found a breakfast cereal that doesn't cost $5 a box that they can eat.
For people whom gluten affects, discovering that all they had to do was stop eating it to become healthy is a life-changing experience, and it can be very obsessing, yes. Personally, I had to struggle to tamp down my impulses to evangelically proselytize about it, and it's easy to argue I wasn't successful; I suspect there are plenty of people who don't put in that effort and just ramble on like fanatics.
No, you couldn't, because conflating your own ignorance regarding the health effects of gluten with the anti-vaxxers ignorance of disease and disdain of public safety is just a sick display of hostile stupidity all around. See to the mote in your own eye.  And yes, I read the article.
Besides the obvious (eating products free of gluten), it can mean a lot of different things to different people. For me, it accompanied a switch to a higher-fat & protein, lower carb diet that has allowed me to put my type 2 diabetes into remission and go medication free. It's also allowed me to indulge in sugars and carbs when I so desire, without (much) negative consequence.
I prefer Icees, but if we look at this comment scientifically, going gluten-free might actually do this, if we consider the healthy state of internal organs to be slush, as opposed to inflamed, amyloid-fibril riddled, and plaque calcified stones requiring chronic pharmacological and surgical treatment just to continue to function.
Tell us how you really feel. There will be a certain level of schadenfreude when people like you get T2 diabetes and lose limbs. Unfortunately, your brain will be too addled for you to understand, so there's no "told you so" satisfaction.
Go home, Michelle Obama, you're drunk.
I'm still trying to imagine packs of dogs out in the waves of grain, harvesting wheat with scythes, milling it, and making their own dog treats. But, hey, you might find the wolves doing it.

Where's "the fuck" ?? It really has no impact if you don't say it right.
Liberals aren't into science; they're into treating scientists as deities and worshiping them, and following group-think trends without any rational basis, but rather the personality of the message bringer. Occasionally, the science is accurate. I could throw research articles at you all day long on pretty much any science topic that politics has migrated into and we'd still have no common ground to discuss the issue because your comprehension is limited by your ideological filters. I know this to be true, because you said "we liberals".
February 10, 2015 Seminal Plasma and Semen Amyloids Enhance Cytomegalovirus Infection in Cell Culture. Not that I expect you to understand this, but there's a possible link of semen amyloid fibril formation to gluten, which means dick isn't necessarily gluten free, and glutened dick might be pretty bad, particularly if it's already bad dick.

Added 2/10/15, 2:00 pm, because I always publish too early.
1. Digestion will break down gluten into its two primary components: gliadin and glutenin, but neither of these are fully digested proteins, nor can they be by humans.
2. In Coeliacs and people sensitive to gluten, the presence of gliadin in the intestinal tract activates the secretion of Zonulin, a protein that regulates the permeability of the intestinal wall.
3. In Coeliacs, the auto-immune response attacks gliadin while it's still in the intestines, in an attempt to prevent it from entering the blood stream through the intestinal wall.  This attack destroys the intestinal villi, leading to serious health problems.
4. In others, gliadin enters the bloodstream in the form of hydrolized gliadin, where it interferes with the normal metabolic process.
5. Gliadin acts as a catalyst for the misfolding of proteins with amylin, a primary regulator of the metabolic process.
6. In Type 1 diabetics, the resulting amyloid (misfolded amylin) fragments collect in the pancreas and are the target of an auto-immune reaction that also destroys the beta cells in the pancreas that produce insulin.
7. Amylin's normal reaction with proteins provides signals which regulate insulin secretion, liver lipid production, brain appetite signals and rate of gastric emptying.
8. When amylin is disrupted by gliadin, so are the signals, resulting in increased insulin secretion, increased lipid production, and appetite signals. Blood sugar will swing, cholesterol and triglycerides will rise, subject will become tired and fatigued, only to rebound to a state of extreme hunger, prompting the continuation of this cycle.
9. In those without a direct auto-immune reaction to gliadin-amyloids, the amyloids fibers will disperse throughout the body and collect in various areas where they will cause inflammation and damage, potentially spark latent auto-immune reactions, or, as in the case of Alzheimer's or atherosclerosis, become the plaques that cause the damage.
10. In others, the prolonged inflammation of the fatty cells, heightened secretion of insulin and liver production of lipids will lead to insulin resistance, type 2 diabetes, non-alcoholic fatty-acid liver disease, kidney failure, along with any other number of related complications.

Tuesday, February 3, 2015

The Big Deal about Gluten

Since the NASCAR superbowl commercial mocking the gluten-free diet, there's been yet another spate of ignorant commentators talking about the gluten-free diet as though they know something, and "offended" Celiacs worrying about being mocked when they say "gluten-free".  Personally, Ricky-Bobby's ignorance doesn't bother me, and I can have a good laugh at anyone mocking my diet, because I consistently feel better than I have in a damned long time, if not ever. The biggest downside is the block it creates in people's minds who might otherwise be open to learning about the actual medical research into the subject,

I haven't been updating my Backlash or Research page lately, but I still read the insanity, and I'm always looking for more research to confirm or spoil my own hypothesis on the matter.

Here's the full text of a student's fabulous master's thesis on the formation of amyloids which I recently discovered.

Kinetics of Peptide Aggregation
Keira C. Ebanks

I have previously referenced the following 2 studies on Amyloid formation:
Peptide Mixtures Can Self-Assemble into Large Amyloid Fibers of Varying Size and Morphology
The Role of Protein Hydrophobicity in Conformation Change and Self-Assembly into Large Amyloid Fibers

However, I don't have access to the full texts of those (and Ebanks is a co-author of the 1st of those 2), while this one anyone can read.

So why is this important?  Because amyloids are linked to a wide number of chronic illnesses, and amyloid formation has been linked directly to hydrolized gliadin, a partially digested protein which is distinct to gluten.

In other words, the problems with eating gluten are much more serious for many more people than confirmed Celiacs. If anything, Celiacs are lucky, because they CAN'T eat gluten (as opposed to Type 1 Diabetics, who are just plain gluten unlucky).  The rest of us just get Atherosclerosis, Type 2 Diabetes, Alzheimer's, or Parkinsons, and then wonder why nothing we do works to slow it or reverse it as we slowly die while living a drug-addled miserable existence.

Oh, and I found out I'm one of the 2.8%, and if I make it another 4 months, I'll be in the exclusive 0.4% club!

Type 2 Diabetes Remission Very Rare in Non-Bariatric Surgery Patients

Sunday, November 23, 2014

The Science of Gluten vs. Stupidity of Journalism

In early May of 2014, after fighting a slow, vicious, and losing battle with type 2 diabetes over 25 years, I decided to try a gluten-free diet based on some readings and testimonials of friends. Having tried multiple diet courses over the years, I was extremely skeptical and pessimistic, and extraordinarily surprised when it worked.  I was so surprised that one, relatively minor dietary change could have such a drastic effect that I have felt compelled since to research the subject and discover why. Many of the claims in the few books I've read are mostly unsubstantiated by other research, which means, scientifically they are just wild speculation as to cause (well-educated guesses, since these books are by doctors).  The proof of the results, however, is undeniable.

In the course of my research, I've come across a multitude of opinion articles against the gluten-free "movement", and for my amusement, I've been collecting links to them. The onslaught of group-think in journalism has forced me to mostly abandon it since late September, when the number of worthless opinions exploded in quantity, but I still try to link the most opinionated articles.  The one common denominator among all of the articles is that the authors really don't know what they're talking about. To be fair, most people following a gluten-free diet may not, either, but in their defense - they know it works, even if not why.  This lack of knowledge on the subject, by both sides, creates a conflict, and if there's anything journalists are good at, it's stroking conflict.  It certainly isn't doing research and reporting on it.

While I also maintain a research page, it's mostly just a place for me to throw links to research that I've found, and I offer little explanation of why that research is important to understanding, or what I've come to understand from it.

The 'Famous' Australian Research Team

If you're a well-read know-it-all, let me begin by addressing Peter Gibson's research studies, since you've probably read ignorant journalists reporting on it, without reading the actual reports, and thus think you know "science" has disproven the gluten-free movement and everyone doing it is an idiot and the whole thing is stupid. Here's how patients were selected for the study:

"Celiac disease was excluded either by absence of the HLA-DQ2 and HLA-DQ8 haplotype or by a normal duodenal biopsy (Marsh 0) performed at endoscopy while on a gluten-containing diet in individuals expressing the HLA-DQ2 or HLA-DQ8 haplotype."

To translate, anyone with a measurable immune response to gliadin (the 'offending' protein in gluten) was excluded from the study as a Celiac. This excluded not only those presenting with Celiac's (specific to gluten induced intestinal damage), but also anyone with a medical diagnosis of non-celiac gluten sensitivity (NCGS), where an autoimmune response may have been measured, but a biopsy may not have been performed or did not show Celiac's damage. Typically, a medical diagnosis of NCGS is derived by a lab test confirming an autoimmune reaction to gliadin, without presenting symptoms of Celiacs. This is opposed to a clinical diagnosis, which is derived solely from a doctor's opinion based on the results of a patient removing gluten from the diet. Then, there are the self-diagnosed, who have reached the conclusion without the assistance of a medical professional. Finally, there are the people in this study, who are both self-diagnosed, and subsequently medically confirmed as NOT having NCGS.

In other words, this study was only on people who were absolutely not, by current testing standards or by prior clinical evaluation, reactive to gluten, and the paper does not give the information on how many people applied for the study vs. how many were rejected, which could be an important, missing data point in a larger picture.

Second, the diets tested in the study specifically separated gluten from FODMAPS.  There was no condition tested where gluten and FODMAPS were studied together, which was THE condition of this team's 1st study that this 2nd study supposedly refutes, so there is no direct comparison data point between the two studies.  From the discussion section of the article:

"Alternatively, gluten might induce symptoms only in the presence of a moderate content of FODMAPs."

In other words, they don't know, mostly because they didn't look, and this may be critical oversight given the most basic understanding of the processes of gliadin related problems, both in Celiacs and other 'alleged' gluten related disorders, which I'll get to in a minute.

Finally, the study was small: 37 people completed 7-days, and only 22 of those stayed for an extra 3-day re-challenge (from which most of the conclusion is derived). This analysis isn't to 'debunk' the study - it's actually an important study, and will ultimately help to differentiate the paths by which gluten harms. It's to debunk the journalistic (ie: moronic) claims associated with the study, which are unfortunately supported by some of the suppositions (not fully substantiated claims stated as reasonable speculation) the researchers put into their conclusion to explain the differences between their 1st and 2nd study.

If you have further interest in Gibson's research team, they also did a 3rd study on gluten, which is usually conveniently ignored by the journalists, who are mostly too stupid or lazy to understand it let alone tease out implications without cribbing someone else's wild, click-bait interpretation of it, first.

Hopefully, addressing the (journalistic) issues around this study is enough to open the average skeptic's mind enough to continue.

The Insulin / Amylin Metabolic Process

Before we even get to gluten, we need to first have an understanding of this aspect of the normal metabolic process: the insulin / amylin process.

Most people are familiar with the insulin process, simply because of the wide prevalence of Diabetes (in all its varieties), and the fact that people like to talk about their problems.  The pancreas produces insulin to control the amount of sugar in the blood.  If the process is disrupted, blood sugar levels can get too high or too low, both of which can be dangerous.  Hypoglycemia and (all forms of) Diabetes are fairly well known disorders associated with insulin disruption.

What most people are not aware of is the amylin process.  The pancreas also produces a protein called amylin, which is the other half of the blood sugar regulation process.  The technical term is Islet Amyloid Polypeptide (IAPP).  In the normal process, amylin is cosecreted with insulin, and it helps regulate blood sugar by being part of the signalling system to the brain which suppresses appetite, slows the digestive process, and slows insulin production.

When the amylin process is disrupted, it simultaneously disrupts the insulin process, as amylin is the regulator of insulin production. Amylin process disruption is a well-known problem in a wide variety of chronic illnesses, but the source of the disruption and the importance of finding the source is generally overlooked in treatment considerations.  In the case of Diabetics (all varieties), the treatments generally only address the insulin disruption, and ignore the amylin disruption.

When the amylin process is disrupted, it is generally because the amylins are not reacting properly with nutrients in the blood plasma. The results of these poor reactions are often termed "amylin residue".  This residue presents as either fragments of amylin peptides, or as fibroids, often termed "amyloids". For the sake of convenience, I'll refer to them all as amyloids (mishapen amylin peptide residue, either as fragments or fibroids).  Amyloids are toxic to the body, and the body seeks to remove them.  Amyloids have a tendency to collect in certain areas of the body, but where they collect varies considerably. This may be determined by the nature of the amyloid itself, likely by which destination the normal version of the peptide was supposed to go.

The removal of amyloids from the body is dealt with in a normal process called autophagy, but in some people, either by genetic variation, or quantity of amyloids, a greater immune response might also kick-in to assist with the removal.  When this happens, there is generally a lot of cell-death in the areas around where the amyloids have been collecting, and there are nasty side effects.

There are a number of chronic illnesses associated with amyloids, including: Type 1 Diabetes, Type 2 Diabetes, Chronic Heart Disease, Alzheimer's Disease, Parkinson's Disease, Rheumatoid Arthritis, and Celiac's Disease.

What has only begun to be studied is what causes the amylin disruption to begin with. Previously, it was uncertain if the amyloids were a cause or a biproduct of the diseases they are associated with, but by seeing that the immune reaction is a response to amyloid collection, many studies are now being focused on the amyloids, and more information should follow in the future.  In the meantime, there is enough information from many completed studies to shed light on a number of conditions.

Gluten and the Amylin Process

Gluten is a protein found in wheat, which has many components, but the one I'll be addressing is called gliadin. When gluten is digested, it is broken down, and one of those results is gliadin - more accurately, hydrolized gliadin.  Hydrolysis is a process of cleaving proteins into smaller components with water, and while gliadin does cleave, the human digestive system is not designed to cleave gliadin into its further basic components (where it would no longer be considered gliadin, but its basic amino acid structures).  So, when you see the term hydrolized gliadin, it is referring to a partially digested substance.  In a normally functioning digestive process, hydrolized gliadin should be discarded, and not allowed into the blood stream through the villi of the small intestine.

Unfortunately, hydrolized gliadin is reactive with amylin.  In the presence of other peptides reacting with amylin (as they are supposed to do in normal function), hydrolized gliadin disrupts amyloid formation. Hydrolized gliadin, like a catalyst, is misfolding the normal amylin reaction process with nutrients, resulting in either leftover fragments, or fibroid production.  Hydrolized gliadin creates amyloids in the presence of amylin and nutrients.

If one now looks back to Gibson's limited 2nd study with this understanding, the result that gluten alone produced no reaction in his study can be seen in an entirely different light. The fact that gluten and FODMAPs weren't tested together can be seen as a critical oversight that may have provided a great deal of information.  If one were a suspicious person, one might suspect this was an intentional oversight, as this process was speculated in medical literature prior to Gibson's study. Gibson is selling low-FODMAP dietary books, so it would be a crying shame if his books were rendered highly irrelevant by the results of his own research team and the current dietary trends.

These types of amyloids are referred to as gluten-peptides or gliadin-peptides, instead of simply as amyloids.  This is an important distinction because gliadin is not the sole source of all amyloids, so when one is looking for a specific amyloid connection to gluten, gliadin-peptides are the distinguishing marker.

Recognizing this process identifies hydrolized gliadin as a potential source of amyloids, which makes it a viable candidate as a source of amyloids in any of the amyloid related diseases - one simply needs to look at the amyloids and determine if they are gluten peptides or not, which science is only beginning to do, and the results of which clearly haven't translated into a broader audience, because journalists are stupid group-think creatures incapable of processing raw information without a spin filter, until there is an overwhelming abundance of information that even they can't deny, and everyone already knows about before they finally report the truth.

Back to examining the metabolic process: we're still left with a barrier that needs to be crossed that shouldn't be; the small intestine.  In the normal digestive process, hydrolized gliadin should be discarded.  It shouldn't have access to the amylins to disrupt the insulin/amylin process to begin with.

Gluten and Intestinal Permeability

If you're well-read, you might have heard ignorant journalists or air-headed health-avid nuts use the term "leaky-gut", which I despise.  It's a layman's term for intestinal permeability that provides no information about the process, and is more designed to induce a low-brow reaction. Intestinal permeability is a description of the ability of the small intestine's villi to allow or reject molecules from passing through into the blood stream.  It does this by tightening or loosening the junctures between the cells.  When the regulation of this permeability is disrupted, molecules that should't pass through, do.

The regulation of intestinal permeability has been linked to a protein called Zonulin, which is generated in the intestine, and controls the junction between cells in the digestive tract. The more Zonulin present, the looser the space between cells, and the greater the possible uptake of larger, not fully cleaved molecules, like hydrolized-gliadin, entering the blood stream.  This regulatory process is a relatively recent discovery (2000), which explains the asinine name assigned to the protein (Zonulin) and why most people aren't familiar with the process, or misunderstand it.

Heightened levels of zonulin in the system have already been linked to a number of chronic illnesses, including Celiacs, Type 1 Diabetes, Type 2 Diabetes, and Parkinson's.

Excessive Zonulin secretion has been linked to the presence of hydrolized gliadin in the digestive system.  In other words, gliadin itself is a stimulator of the release of zonulin, which then allow hydrolized gliadin to pass into the blood stream where it can more easily create gluten-peptides (amyloids).

Gliadin isn't the only stimulator of Zonulin release - it's also been linked to bacterial and viral infections, and other sources are suspected (like glyphosate), but haven't been confirmed.  Also, research shows a wide difference between Gliadin's stimulation of zonulin between normal individuals, and those already diagnosed with gluten-related disorders.  In normal individuals, gliadin still stimulates additional zonulin production, but not to the degree of those already known to be suffering from gluten reactions (primarily Celiac and Type 1 sufferers).

In other words, some unknown, environmental factor may be a trigger which turns on excessive zonulin production in reaction to gliadin, which once turned on, doesn't seem to turn off.  While this probably means, in a larger, undiscovered picture, that gluten is not the end-all-be-all evil of food consumption, it also means that once the body reacts to it in this fashion (ie: zonulin disruption, amyloid production, and/or auto-immune attack), it doesn't matter - the most effective treatment will be to remove gluten from the diet.

Let me reiterate: the primary cause of the zonulin process disruption is unknown, but once disrupted, gliadin is an amplifying source of that disruption.

The Many Competing Theories:

Modern Wheat is dangerous! This is the premise of Wheat Belly.  The hybrid wheat that spawned the "2nd Green Revolution" in the 60's doubled the number of chromosones in the wheat, and introduced a type of gliadin into gluten which had never before been in the human diet: gliadin-d. It's been a while since I read it, but I consider it mostly bunk because I haven't found a single study that bothers denoting a difference in gluten types, or comparison of reactions to gluten type, or found any bothersome problems from additional chromosones, etc.  While there might be some differences and problems for some people, the rise in T1 & T2 diabetes, obesity, celiac disease, et al. didn't start until the 70's, and didn't accelerate noticeably until the 90's.

Modern Wheat has More Gluten! While it's possible that the rise in gluten related problems is due simply to the increased amount of gluten in people's diet, there is no indication I've found that modern wheat has a greater quantity of gluten in it than prior.  I've seen competing claims about the amount of wheat consumed rising, or being the same, historically, so there's nothing clear about this.

GMO, GMO, GMO! No varieties of wheat in the commercial market are GMO, so this is just idiocy. In fact, it's my understanding that most GMO crops, like Corn and Soy, are actually using genes from wheat in the splicing, not the other way around.

Bromine Poisoning.  Most baked goods add potassium bromide (or other bromine salt) to wheat flours for structural integrity and longevity.  Bromine is known to replace sodium chloride and iodine in the body's many salt processes, and can be particularly damaging to the thyroid and pituitary glands, as well as greatly disrupt blood pressure.  I've found no studies on bromine's affect on the gut, however, so its place in intestinal damage is unknown.  Still, a good idea to cut this crap out of your diet if you have blood pressure or glandular issues.

Your Wheat is Poisoned!  What seems the most conspiratorial claim of all is probably the most likely. A common practice in harvesting wheat (and many other crops) is to spray it with glyphosate (RoundUp) or another weed killer a couple of days beforehand, forcing it to go to seed before it dies, and to help desiccate the crop for easier harvest and sorting.  Glyphosate soaks into the seeds (the part you eat) and doesn't wash out, and glyphosate poisoning is known to damage the intestinal membrane (villi), perhaps sparking the zonulin disruption, and then the amyloid disruption.

The timeline of the use of glyphosate is also incriminating; it was first used in the 70's (patented in 1974), coinciding with the initial rise in public health problems related to diet, but it wasn't until the 90's that it saw widespread use with newly introduced GMO crops, and the practice of spraying before harvest became widely used.

The newer studies on glyphosate are beginning to back up these claims, both as being more poisonous to humans than originally claimed (the "nonactive" additives aren't part of the studies), and as being damaging to the intestine, and mimicking or creating gluten sensitivity problems.

So what's the answer? Hell if I know for certain (though I seem to know more than any single journalist, whose job is supposed to be to research and report this stuff).  What I do know is going gluten-free has been life changing for me, and for every T2 diabetic who's listened to me long enough to try it, and for my wife's immune problems, and even for my kids (who certainly don't appreciate it, yet).

So, if you're still caught on the "it's just a fad" bandwagon, well, put some shut the fuck up in your own diet.

Are You a Stupid Journalist?

If you are a stupid journalist, and you're aggravated that I haven't bothered to footnote and link my references - please visit this research link page, where I throw links in a mostly unorganized fashion.

Better yet: do your own fucking research you lazy turd; it's all out there, and if someone like me can find it all and derive a basic understanding without resorting to reading other half-wits, you possibly could, too.  If you had tried to begin with, you wouldn't have wasted time and potentially endangered lives by laughing off gluten-free as a "fad" with your asinine ignorant opinions.

A small list of asinine ignorant opinions, proving that you (stupid journalist) are just a cow in the herd and haven't done your job or offered an original thought on the subject.

This was going to be a much longer article, but I've grown frustrated with the topic, since scientists are lollygagging on the additional research that needs to be done, journalists are nothing more than groupthink moths, and with everyone else I'm either preaching to the choir or to the deaf.  I've sat on finishing it for a couple of weeks, and now I'm just rushing it out to clear it out of my posts.

Since going gluten-free, I've been catching up on projects and goals I've been putting off for years, and I've been putting this aside, and probably will again after I post this.  I was hoping to expand the explanations of the different amyloid diseases, show the proof of gliadin peptides in T1 Diabetes, the proof of amyloids in T2 diabetes, Alzheimers, etc. and show the suspicions of gluten peptides as the cause, and then try to dive into the gut bacteria/mental health connections. Then I realized no one really gives a shit if it means they can't have their bread or pizza, so obviously the best conclusion that allows me to retain my sanity yet still feel like I've done something is to just get it the hell out of my post que, link it for friends & assholes in the future, and then try not feel bad for them (and especially not feel schadenfreude) when they ignore it and get sick anyway.

Back to living.

Sunday, October 12, 2014

The Pumpkin Pie w/Gluten Free Crust That Almost Wasn't.

Once upon a time, Catherine fell in love with an overpriced drink from Starbucks, which she would buy as often as she could afford, but it was a seasonal flavor, and seasons end. This particular season was fall, and this particular flavor was Pumpkin Spice coffee, which you've probably already deduced, given its power of seduction over American females far and wide.
She missed her drink so much, she endeavored to recreated the flavor on her own, investing her limited free time, experimenting like a mad scientist with cans of pumpkin pie filling and exotic spices. There were disasters, and then breakthroughs, and many pots for the whole family to clean.
Eventually, the recipe was perfected, and for months she had but one complaint: it's too chunky. She used bigger words, but the end result was that the residue from the pumpkin settled in her coffee so that finishing a cup of Pumpkin Spice coffee was never as good as starting it.
So she added a final step to her preparations: straining. After boiling her pumpkin pie filling with her secret blend of spices, she would strain the delicious goodness into a bottle, which when mixed in the coffee still created the desired flavor, but left no gritty mess at the bottom of her breakfast blend.
One day her husband walked through the kitchen during her process of straining and wondered aloud: "What do you do with the left overs?" He knew full well that she discarded the leftovers, since the refrigerator wasn't stuffed with tupperware brimmed with pumpkin pie filling, but he had a bit of thrifty hoarder in him, and it pained him to see perfectly good paid for product being discarded that might still have a use.
When he noticed later that week a bowl being filled with pumpkin pie filling, the sense of the coming season (Halloween!) enticed him to find some gluten free pie crusts on his next shopping stop. It had to be gluten free, of course, as her husband had been sucked into the current dietary fad with promises of curing the problems of non-celiac gluten sensitivity he never knew he had.  Though he was loathe to spend $5.00 on 2 measly pie crusts, he overcame his reluctance and made the purchase with visions of desert and Thanksgiving in his head.
So he mixed up the leftovers with some condensed milk, a little sugar, a pinch of salt, and baked it at 450 for 15 minutes, then at 350 for 45 minutes, and it came out perfect, especially with some whipped cream on top.

Monday, September 8, 2014

Faith Based Corruption and Compromise

Anyone remember George W. Bush's Faith Based Initiative Program?  In 2001, an executive order opened up the federal coffers, under a newly created branch of the executive office, to any and all organizations of faith involved in community services that overlapped with Federal programs.  The Catch 22, of course, was that in order to receive money, any organization's involvement with the Federal funding had to be contingent upon them not talking about, thinking about, or acting on their actual faith.

This was called: "compassionate conservatism".  Now, instead of relying on people's tithing and volunteerism, advertising their presence in the community and preaching the word of God as they engaged in his work, Churches could just apply for a grant, do the same thing, just quietly, and wear emblazoned t-shirts and have a sign hanging behind them and hope that was enough to get some sort of message through.  It was a true compromise of ethics; both of the government's role as protector of religious freedom by standing apart, and of any faith based organization willing to take on the burden of increased government oversight, control, and regulation of their activities.

While clearly of good intentions, it stirred up a number of fears, criticisms, and lawsuits during the Bush administration.  Many were concerned about pagans, satanists and other fringe "religions" getting their hands on government money and abusing the non-secular public-use clauses guarding the hen house.  Some were concerned radical Muslim groups posing as charities would funnel grant money to terrorist organizations. Only a few bothered to point out what should have been the most obvious concern: "Whenever you take the government shekels, sooner or later comes the government's shackles."

The threat was never an external one; it was the gall of any of these organizations to believe that their own faith is not corruptible.

When Obama was elected, one of the first things he did was to rename the faith based initiative office. It was previously called: "White House Office of Faith-Based and Community Initiatives", and in an executive order on Feb 5, 2009 (one of his first), officially renamed it to the: "White House Office of Faith-Based and Neighborhood Partnerships"

This is important, because this wording entirely changes the nature of the grant program by removing any veil that the government is simply awarding money to good causes.  It is no longer a "community initiative", now it's a partnership with the government.  Yes, annoying people may parse the sentence and interpret the words entirely differently just to be annoying, but the fact remains: the purpose of the funding is no longer to empower faith-based community initiatives, it is to partner with the government to receive funding for government goals under the guise of social services.  I would argue that it was always this.

Was there any media mention, let alone a months-long uproar with opinion pages splattering useless critical/complementary opinions, over this name-change?  Has there been any media coverage or mention of the Office of Faith-Based Partnerships since 2009?  I certainly don't recall it being on anyone's media radar since Bush left office.

So, since 2001, the government has slowly been extending its grasp and control over Faith-Based programs in need of money for social services, until in 2009, these social services openly became "partnerships" with the government, and the grants evolved into a daily listing for social services on some Federal webpage, where anyone willing to sacrifice their religious freedoms in the name of their religion could apply and get money to do God's work without involving God, based on what the government wants to fund and how it wants to fund it, which may or may not overlap with what people of faith should be doing to serve God.

While I'm certain there are thousands of examples of abuse of this system prior, nothing exemplifies this perversion and corruption of the already compromising faith-based "partnership" than the current crisis of illegal immigrant children flooding across the U.S. borders.

The government started advertising for temporary housing for massive numbers of illegals even before they showed up, and they're still advertising now.  They advertised for security for their internment housing of illegals as they were caught coming in.  They advertised for shipping the illegals around the country.

What was once a slow burn of corruption and moral compromise through political funding has now turned into a waterfall.

How much money does it take for a Baptist to call himself a "Brown-Shirt"?  What good service in the name of God allows for the sort of compromise where you can justify hiding the truth from people, threatening health workers, and adopting a self-described moniker evocative one of the most vile and inhuman eras of history?

The Baptist Brown-Shirts.  Dwell on that for a minute, if you're wondering how deep and disturbing this corruption of faith in service of the government really is.

Of course it's spread much further than that; the uproar over illegal children being shipped around the country is raising hackles and opening a number of eyes to see that their own Churches may be dealing directly with DHS.

NY church backs out of federal plan to house illegal immigrant children - not because anyone cried foul - they just missed the application deadline.

A good bulk of information on Churches using government money to care for illegal immigrants can be found here: Refugee Resettlement Watch.  I'd link individual articles, but this site is pretty expansive, and I work for a living.  It's not just Baptists.  It's Catholics, Lutherans, Hebrews, A variety of evangelical groups... ironically, the only groups I've not seen signing up to house illegal children are Islamic groups, though it wouldn't surprise me at all if there are and even the loudmouthed conservatives are holding back reporting on it out of fear.

To anyone looking, the conclusion that the flood of illegal immigrant children is an "engineered" crisis is not difficult to reach.  It is clearly intentional, and was planned by the government, and enacted to be as detrimental, dehumanizing, demoralizing and divisive to the actual American citizenry as possible. Religious organizations that seek funding in order to assist these illegals are truly partnering with and enabling the government. 

Oh, certainly; these children do need help, and the churches should be involved - but on their own terms. To surrender your faith and freedoms in exchange for funding makes you even less than a partner; it makes you a parasite - because the government is not responding to a social problem; it's creating it. Churches involved in this are not being charitable - they're profiteering.  You can delude yourself that what good you're doing outweighs the ills you accept in order to do so, but this is a fool's argument: the ends never justify the means. Fouled actions taint all outcomes.

Find out if your Church or Organization is accepting government funding, any arena, and urge them out of it.